Synthesis and Biological Evaluation of Aminonaphthols Incorporated Indole Derivatives

Synthesis and Biological Evaluation of Aminonaphthols Incorporated Indole Derivatives

An efficient one pot condensation of naphthols (1), 2,5-disubstituted indole-3-carboxaldehydes (2), and secondary amines (3) has been achieved using dichloromethane as a solvent, stirring at room temperature. Some of the new [(disubstituted amino)(5-substituted 2-phenyl-1H-indol-3-yl)methyl]naphthalene-ols (4) derivatives were prepared in good yields. The significant features of this method are...

synthesis and biological evaluation of new indole hydrazone derivatives as platelet aggregation inhibitors

Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives

Six new titanocene compounds have been isolated and characterised. These compounds were synthesised from their fulvene precursors using Super Hydride (LiBEt3H) followed by transmetallation with titanium tetrachloride to yield the corresponding titanocene dichloride derivatives. These complexes are bis-[((1-methyl-3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (...

Design, Synthesis and biological evaluation of some novel indole derivatives as selective COX-2 inhibitors

Article history: Received on: 28/06/2017 Accepted on: 05/08/2017 Available online: 30/08/2017 A new group of (4-substitutedphenyl)(3-((2-(4substitutedphenyl)hydrazono)methyl)-1H-indol-1-yl)methanone derivatives 13a-f as indomethacin analogs was synthesized through N-benzoylation of indole-3-cabaldehyde with the appropriate benzoyl fragment followed by reaction with substituted phenylhydrazine. ...

Synthesis of new indole derivatives structurally related to donepezil and their biological evaluation as acetylcholinesterase inhibitors.

New series of indole derivatives analogous to donepezil, a well known anti-Alzheimer and acetylcholinesterase inhibitor drug, was synthesized. A full chemical characterization of the new compounds is provided. Biological evaluation of the new compounds as acetylcholinesterase inhibitors was performed. Most of the compounds were found to have potent acetylcholinesterase inhibitor activity compar...